Nitrazepam has become connected to critical hepatic Diseases, comparable to other nitrobenzodiazepines. Nitrobenzodiazepines which include nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more toxic to the liver than other benzodiazepines as they are metabolically activated by CYP3A4 which may end up in cytotoxicity.Tolerance to ni